Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0589 | 0.7127 | 0.7116 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0045 | 0.0154 | 0.0115 |
Entamoeba histolytica | hypothetical protein | 0.0045 | 0.0154 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0045 | 0.0154 | 0.027 |
Brugia malayi | follicle stimulating hormone receptor | 0.0248 | 0.2765 | 0.4841 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0195 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0078 | 0.0573 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0401 | 0.4715 | 0.4694 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0248 | 0.2765 | 0.3879 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0045 | 0.0154 | 0.0115 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0045 | 0.0154 | 0.0217 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0078 | 0.0573 | 0.1004 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0123 | 0.115 | 0.2013 |
Echinococcus granulosus | glutamate receptor 2 | 0.0045 | 0.0154 | 0.0161 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0045 | 0.0154 | 0.0217 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0161 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0195 | 0.0342 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0123 | 0.115 | 0.1613 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0045 | 0.0154 | 0.5 |
Leishmania major | extracellular receptor, putative | 0.0045 | 0.0154 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0589 | 0.7127 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0401 | 0.4715 | 0.6596 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.115 | 0.1613 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0401 | 0.4715 | 0.7197 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0045 | 0.0154 | 0.0217 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0045 | 0.0154 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.004 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.7127 | 1 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0045 | 0.0154 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0573 | 0.0875 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0433 | 0.5134 | 0.899 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0154 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0078 | 0.0573 | 0.0752 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0478 | 0.571 | 1 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0045 | 0.0154 | 0.0161 |
Schistosoma mansoni | protein kinase | 0.0045 | 0.0154 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0195 | 0.0274 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0544 | 0.6551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0045 | 0.0154 | 0.0161 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0045 | 0.0154 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0154 | 0.0217 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0233 | 0.2567 | 0.4495 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0045 | 0.0154 | 0.0236 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0045 | 0.0154 | 0.0115 |
Loa Loa (eye worm) | glutamate receptor | 0.0188 | 0.199 | 0.2792 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.004 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0154 | 0.027 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0154 | 0.0236 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0045 | 0.0154 | 0.0161 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0045 | 0.0154 | 0.0217 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0115 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0115 |
Echinococcus granulosus | glutamate receptor 2 | 0.0045 | 0.0154 | 0.0161 |
Brugia malayi | hypothetical protein | 0.0036 | 0.004 | 0.007 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0195 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0573 | 0.0804 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0233 | 0.2567 | 0.3918 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0045 | 0.0154 | 0.0115 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0045 | 0.0154 | 0.027 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0045 | 0.0154 | 0.0115 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0115 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0045 | 0.0154 | 0.0161 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0078 | 0.0573 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0078 | 0.0573 | 0.0535 |
Echinococcus multilocularis | tyrosine kinase | 0.0045 | 0.0154 | 0.0115 |
Loa Loa (eye worm) | glutamate receptor | 0.0478 | 0.571 | 0.8012 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0123 | 0.115 | 0.1613 |
Echinococcus granulosus | tyrosine kinase | 0.0045 | 0.0154 | 0.0161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.