Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.028 | 0.3327 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.0932 | 0.8342 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0734 | 0.989 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.0932 | 0.8342 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.0932 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.1117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.3327 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.0932 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.0932 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.1117 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.0932 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.1117 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.028 | 0.3327 | 0.5149 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.3327 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0497 | 0.6461 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.1117 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.