Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | type A flavoprotein, putative | 0.0022 | 0.2194 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0022 | 0.2194 | 0.2194 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.8563 | 0.5 |
Treponema pallidum | flavodoxin | 0.0022 | 0.2194 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0022 | 0.2194 | 0.2194 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0058 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0058 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0058 | 1 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0022 | 0.2194 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0058 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0058 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0036 | 0.5165 | 0.5165 |
Brugia malayi | FAD binding domain containing protein | 0.0058 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0052 | 0.8563 | 0.8159 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0058 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0058 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0036 | 0.5165 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0058 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0058 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0029 | 0.3727 | 0.3727 |
Leishmania major | cytochrome P450 reductase, putative | 0.0052 | 0.8563 | 0.8159 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0022 | 0.2194 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0036 | 0.5165 | 0.5165 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0029 | 0.3631 | 0.3631 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0058 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0036 | 0.5165 | 0.5165 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.3631 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0058 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0036 | 0.5165 | 0.5165 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0.3631 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0036 | 0.5165 | 0.5165 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.8563 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0058 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0058 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Plasmodium vivax | flavodoxin domain containing protein | 0.0052 | 0.8563 | 0.8159 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0058 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0022 | 0.2194 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0058 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0058 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0022 | 0.2194 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.