Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.3455 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.063 | 0.6249 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.1372 | 0.3967 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0597 | 0.5901 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.063 | 0.6249 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0597 | 0.5901 | 0.9443 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0597 | 0.5901 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0597 | 0.5901 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0316 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0149 | 0.1091 | 0.1684 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0198 | 0.0197 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0198 | 0.0571 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.1372 | 0.2193 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0019 | 0.005 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.063 | 0.6249 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0019 | 0.005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0316 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0046 | 0.0072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0316 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0019 | 0.005 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0597 | 0.5901 | 0.5 |
Plasmodium vivax | cell division cycle ATPase, putative | 0.0228 | 0.1939 | 0.3234 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0198 | 0.0316 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0198 | 0.0571 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.063 | 0.6249 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0377 | 0.3536 | 0.5627 |
Giardia lamblia | AAA family ATPase | 0.0377 | 0.3536 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0377 | 0.3536 | 0.5627 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.1372 | 0.3967 |
Brugia malayi | vesicle-fusing ATPase | 0.0369 | 0.3455 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0597 | 0.5901 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.063 | 0.6249 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0369 | 0.3455 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0377 | 0.3536 | 0.5 |
Brugia malayi | valosin containing protein | 0.0369 | 0.3455 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0198 | 0.0571 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.026 | 0.2287 | 0.2286 |
Loa Loa (eye worm) | VCP protein | 0.026 | 0.2287 | 0.6618 |
Mycobacterium ulcerans | ATPase | 0.0377 | 0.3536 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.026 | 0.2287 | 0.3659 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0198 | 0.0571 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.026 | 0.2287 | 0.6618 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0149 | 0.1091 | 0.1684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0316 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0198 | 0.0571 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.063 | 0.6249 | 0.6248 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.1372 | 0.1371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0198 | 0.0316 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0019 | 0.005 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0597 | 0.5901 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.1319 | 0.2109 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0198 | 0.0571 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0597 | 0.5901 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.