Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0605 | 0.9326 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.0382 | 0.4742 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0605 | 0.9326 | 0.9122 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0605 | 0.9326 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.0382 | 0.4742 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0638 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0605 | 0.9326 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0638 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0374 | 0.4584 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0605 | 0.9326 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0605 | 0.9326 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0638 | 1 | 0.5 |
Brugia malayi | valosin containing protein | 0.0374 | 0.4584 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0638 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0605 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0638 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0382 | 0.4742 | 0.0000097958 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0374 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0605 | 0.9326 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0382 | 0.4742 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.