Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0116 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | GMP reductase | 0.0205 | 0.2482 | 0.2482 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0493 | 1 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0493 | 1 | 0.5 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0258 | 0.3883 | 0.3189 |
Onchocerca volvulus | Putative GMP reductase | 0.0205 | 0.2482 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0493 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0258 | 0.3883 | 0.3189 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0493 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0493 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0493 | 1 | 0.5 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0258 | 0.3883 | 0.3189 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0258 | 0.3883 | 0.3189 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0463 | 0.9236 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0493 | 1 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0116 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.3883 | 0.3883 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0463 | 0.9236 | 0.5 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0258 | 0.3883 | 0.3189 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0259 | 0.389 | 0.0954 |
Brugia malayi | alpha1,3-fucosyltransferase homologue | 0.0258 | 0.3883 | 0.1863 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0493 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0493 | 1 | 0.5 |
Loa Loa (eye worm) | fucosyl transferase | 0.0258 | 0.3883 | 0.3883 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0463 | 0.9236 | 0.8869 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0493 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0116 | 0.0154 | 0.0154 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0493 | 1 | 0.5 |
Brugia malayi | Fucosyl transferase family protein | 0.0258 | 0.3883 | 0.1863 |
Leishmania major | guanosine monophosphate reductase | 0.0493 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0493 | 1 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0493 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0493 | 1 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0493 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0493 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0493 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.