Detailed information for compound 831215

Basic information

Technical information
  • TDR Targets ID: 831215
  • Name: N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]-2 ,4-dimethyl-1,3-thiazole-5-carboxamide
  • MW: 284.358 | Formula: C10H12N4O2S2
  • H donors: 1 H acceptors: 4 LogP: 1.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1nnc(s1)NC(=O)c1sc(nc1C)C
  • InChi: 1S/C10H12N4O2S2/c1-5-8(17-6(2)11-5)9(15)12-10-14-13-7(18-10)4-16-3/h4H2,1-3H3,(H,12,14,15)
  • InChiKey: LQZUGDJJKMUPFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]-2,4-dimethyl-thiazole-5-carboxamide
  • N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]-2,4-dimethyl-5-thiazolecarboxamide
  • ZINC07995451

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Schistosoma mansoni tyrosinase precursor 0.0095 0.1156 1
Onchocerca volvulus 0.0061 0.054 0.1403
Plasmodium vivax SET domain protein, putative 0.0031 0 0.5
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.2101 0.165
Onchocerca volvulus 0.0095 0.1156 0.3003
Onchocerca volvulus 0.0061 0.054 0.1403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0539 0.4659
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1156 0.3487
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.054 0.9148 1
Schistosoma mansoni tyrosinase precursor 0.0095 0.1156 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.1156 0.3487
Schistosoma mansoni o-methyltransferase 0.0061 0.054 0.4671
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0539 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0539 0.4659
Onchocerca volvulus 0.0095 0.1156 0.3003
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.2101 0.1813
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.1156 0.3487
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0539 1
Brugia malayi jmjC domain containing protein 0.0061 0.0539 0.1625
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1156 0.3487
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.1156 0.3487
Schistosoma mansoni o-methyltransferase 0.0061 0.054 0.4671
Mycobacterium leprae Possible D-ribose-binding protein 0.054 0.9148 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0526 0.8904 1
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.054 0.9148 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4882 0.5
Brugia malayi O-methyltransferase 0.0061 0.054 0.1629
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.4882 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Brugia malayi jmjC domain containing protein 0.0061 0.0539 0.1625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Loa Loa (eye worm) tyrosinase 1 0.0095 0.1156 0.3487
Brugia malayi O-methyltransferase family protein 0.0061 0.054 0.1629
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0539 1
Schistosoma mansoni o-methyltransferase 0.0061 0.054 0.4671
Onchocerca volvulus 0.0245 0.3851 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.4882 0.5
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.1156 0.3487
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.3317 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0539 0.1625
Onchocerca volvulus 0.0095 0.1156 0.3003
Brugia malayi O-methyltransferase family protein 0.0061 0.054 0.1629
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.1156 0.3487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 0.3487
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0061 0.054 0.5
Loa Loa (eye worm) O-methyltransferase 0.0061 0.054 0.1629
Onchocerca volvulus 0.0095 0.1156 0.3003
Schistosoma mansoni o-methyltransferase 0.0061 0.054 0.4671
Loa Loa (eye worm) hypothetical protein 0.0061 0.054 0.1629
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.2101 0.1866
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0539 0.4659
Brugia malayi ShTK domain containing protein 0.0095 0.1156 0.3487
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0539 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.4882 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 0.3487
Brugia malayi O-methyltransferase family protein 0.0061 0.054 0.1629
Brugia malayi Pre-SET motif family protein 0.0215 0.3317 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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