Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0891 | 1 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0845 | 0.9326 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0891 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0368 | 0.232 | 0.2133 |
Loa Loa (eye worm) | VCP protein | 0.0368 | 0.232 | 0.4791 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.0533 | 0.4742 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0891 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0845 | 0.9326 | 0.5 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0368 | 0.232 | 0.4791 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0533 | 0.4742 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0845 | 0.9326 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0522 | 0.4584 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0845 | 0.9326 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0845 | 0.9326 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0845 | 0.9326 | 1 |
Mycobacterium ulcerans | ATPase | 0.0533 | 0.4742 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0533 | 0.4742 | 0.0000097958 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0522 | 0.4584 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0845 | 0.9326 | 0.9122 |
Brugia malayi | valosin containing protein | 0.0522 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0891 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0845 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0891 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.