Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin b | 0.1165 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0426 | 0.1854 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0258 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1165 | 1 | 1 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1165 | 1 | 1 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Loa Loa (eye worm) | cathepsin B | 0.0426 | 0.1854 | 0.1854 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Plasmodium vivax | vivapain-2 | 0.0258 | 0 | 0.5 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0426 | 0.1854 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0258 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0258 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0258 | 0 | 0.5 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1165 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0426 | 0.1854 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.1165 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1165 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0426 | 0.1854 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0258 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0426 | 0.1854 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0258 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0426 | 0.1854 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0426 | 0.1854 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0426 | 0.1854 | 0.1854 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.1165 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0258 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0426 | 0.1854 | 0.1854 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0258 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0258 | 0 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0258 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0258 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.1165 | 1 | 1 |
Onchocerca volvulus | 0.0258 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.