Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | galactosylceramidase | No references | |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable F420 biosynthesis protein FbiB | 0.0055 | 0 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.2969 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein Acg | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0055 | 0 | 0.5 |
Entamoeba histolytica | nitroreductase family protein | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable F420 biosynthesis protein FbiB | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | nitroreductase | 0.0055 | 0 | 0.5 |
Giardia lamblia | Nitroreductase family protein fused to ferredoxin domain Fd-NR1 | 0.0055 | 0 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2522 | 1 |
Entamoeba histolytica | nitroreductase family protein | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | F420-0--gamma-glutamyl ligase | 0.0055 | 0 | 0.5 |
Trypanosoma cruzi | nitroreductase | 0.0624 | 0.7315 | 0.5 |
Mycobacterium ulcerans | nitroreductase | 0.0055 | 0 | 0.5 |
Mycobacterium leprae | Possible oxidoreductase | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0055 | 0 | 0.5 |
Giardia lamblia | Nitroreductase family protein | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0055 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative oxidoreductase | 0.0055 | 0 | 0.5 |
Giardia lamblia | Nitroreductase Fd-NR2 | 0.0055 | 0 | 0.5 |
Trypanosoma brucei | nitroreductase | 0.0624 | 0.7315 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0055 | 0 | 0.5 |
Trypanosoma cruzi | nitroreductase | 0.0624 | 0.7315 | 0.5 |
Leishmania major | nitroreductase-like protein | 0.0624 | 0.7315 | 1 |
Onchocerca volvulus | 0.0286 | 0.2969 | 1 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | nitroreductase | 0.0055 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2522 | 1 |
Entamoeba histolytica | nitroreductase family protein | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | nitroreductase | 0.0055 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.