Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0063 | 0.0115 | 0.5 | |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0106 | 0.0661 | 0.0858 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0063 | 0.0115 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0244 | 0.2411 | 0.361 |
Schistosoma mansoni | o-methyltransferase | 0.0063 | 0.0115 | 1 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0244 | 0.2411 | 0.3748 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0054 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.6474 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0063 | 0.0115 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.9891 | 1 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0546 | 0.6239 | 1 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0244 | 0.2411 | 0.3314 |
Loa Loa (eye worm) | IRE protein kinase | 0.0106 | 0.0661 | 1 |
Mycobacterium ulcerans | O-methyltransferase | 0.0609 | 0.7041 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0063 | 0.0115 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0063 | 0.0115 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0106 | 0.0661 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.0115 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.0106 | 0.0661 | 0.5 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0063 | 0.0115 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | > 5 mg kg-1 | Dose required to reverse mCPP induced hypolocomotion by 50% at 7 mg/kg, ip administration 30 min pretest | ChEMBL. | 10969986 |
Ki (binding) | = -8.8 | Binding affinity towards human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by displacement of [3H]-mesulergine | ChEMBL. | 10969986 |
Ki (binding) | = -7.4 | Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]-5-HT | ChEMBL. | 10969986 |
Ki (binding) | = -6.6 | Binding affinity towards human cloned 5-hydroxytryptamine 2A receptor of HEK293 cells by displacement of [3H]-ketanserin | ChEMBL. | 10969986 |
Log Ki (binding) | = 6.6 | Binding affinity towards human cloned 5-hydroxytryptamine 2A receptor of HEK293 cells by displacement of [3H]-ketanserin | ChEMBL. | 10969986 |
Log Ki (binding) | = 7.4 | Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]-5-HT | ChEMBL. | 10969986 |
Log Ki (binding) | = 8.8 | Binding affinity towards human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by displacement of [3H]-mesulergine | ChEMBL. | 10969986 |
Selectivity (binding) | = 25 | Selectivity expressed as ratio of serotonin 5-HT2C receptor over serotonin 5-HT2B receptor | ChEMBL. | 10969986 |
Selectivity (binding) | = 160 | Selectivity expressed as ratio of serotonin 5-HT2C receptor over serotonin 5-HT2A receptor | ChEMBL. | 10969986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.