Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-activating factor receptor | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g-protein coupled receptor | platelet-activating factor receptor | 342 aa | 302 aa | 22.2 % |
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0106 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0106 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0106 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0106 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0106 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0106 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 uM | Evaluated for inhibition of slow reacting substance of anaphylaxis (SRS-A) induced contractions in guinea pig ileum strips | ChEMBL. | 2879917 |
IC50 (binding) | = 5 uM | Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand | ChEMBL. | 3339617 |
IC50 (binding) | = 5 uM | Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand | ChEMBL. | 3339617 |
IC50 (binding) | > 10 uM | Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | ChEMBL. | 2879917 |
IC50 (binding) | > 10 uM | Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | ChEMBL. | 2879917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.