Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0031 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0029 | 0.9326 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0029 | 0.9326 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0031 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0018 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.0019 | 0.4742 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.4584 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0029 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0029 | 0.9326 | 0.9122 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0029 | 0.9326 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.0019 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0018 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0029 | 0.9326 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0019 | 0.4742 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0029 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0019 | 0.4742 | 0.0000097958 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0031 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.0018 | 0.4584 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0031 | 1 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0031 | 1 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0029 | 0.9326 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.