Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0013 | 0.054 | 0.0558 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0013 | 0.054 | 0.0541 |
Loa Loa (eye worm) | amidase | 0.0013 | 0.054 | 0.0792 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0013 | 0.054 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.011 | 0.6815 | 0.6826 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0013 | 0.054 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0013 | 0.054 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0013 | 0.054 | 0.5 |
Schistosoma mansoni | amidase | 0.011 | 0.6815 | 0.7041 |
Echinococcus granulosus | transient receptor potential cation channel | 0.016 | 0.9985 | 1 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.054 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0013 | 0.054 | 0.5 |
Brugia malayi | Amidase family protein | 0.0013 | 0.054 | 0.0792 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.054 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0013 | 0.054 | 0.0558 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.011 | 0.6815 | 0.6815 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0013 | 0.054 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0013 | 0.054 | 0.054 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.054 | 0.5 |
Loa Loa (eye worm) | amidase | 0.0013 | 0.054 | 0.0792 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0013 | 0.054 | 0.5 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0013 | 0.054 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0005 | 0.00000010487 | 0.00000010487 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0013 | 0.054 | 0.054 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.011 | 0.6815 | 0.6815 |
Trypanosoma cruzi | amidase, putative | 0.0013 | 0.054 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.054 | 0.5 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0155 | 0.9679 | 0.9679 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0013 | 0.054 | 0.5 |
Brugia malayi | Amidase family protein | 0.0013 | 0.054 | 0.0792 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0013 | 0.054 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.011 | 0.6815 | 0.6826 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0155 | 0.9679 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.011 | 0.6815 | 0.7041 |
Echinococcus granulosus | ankyrin repeat protein | 0.0155 | 0.9679 | 0.9694 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.054 | 0.5 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0013 | 0.054 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0013 | 0.054 | 0.5 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0013 | 0.054 | 0.5 |
Brugia malayi | amidase | 0.011 | 0.6815 | 1 |
Brugia malayi | putative amidase | 0.0013 | 0.054 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.6815 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0013 | 0.054 | 0.0541 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0005 | 0.00000010487 | 0.00000010503 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0013 | 0.054 | 0.5 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0013 | 0.054 | 0.5 |
Trypanosoma cruzi | amidase, putative | 0.0013 | 0.054 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0013 | 0.054 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.