Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.7504 | 0.876 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.3191 | 0.3726 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0476 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0412 | 0.8566 | 0.8566 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.3629 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0476 | 1 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3191 | 0.3726 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0412 | 0.8566 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.072 | 0.084 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0412 | 0.8566 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0476 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0476 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.8566 | 0.8566 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0412 | 0.8566 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.7504 | 0.876 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3191 | 0.3726 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.3629 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0468 | 0.0546 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.7504 | 0.876 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0051 | 0.0468 | 0.0546 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0476 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.7504 | 0.876 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.4044 | 0.4044 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0637 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0051 | 0.0468 | 0.0546 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0051 | 0.0468 | 0.0546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.