Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0752 | 0.4302 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0752 | 0.4302 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0752 | 0.4302 | 0.6976 |
Echinococcus multilocularis | kinesin family 1 | 0.1042 | 0.6688 | 0.687 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0291 | 0.0509 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0975 | 0.6138 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.4302 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.1042 | 0.6688 | 0.6666 |
Onchocerca volvulus | 0.0237 | 0.0066 | 0.5 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.1409 | 0.9705 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1279 | 0.2865 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0291 | 0.0509 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0291 | 0.0509 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0907 | 0.5575 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0752 | 0.4302 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23.8 uM | Inhibitory activity against human platelet aggregation. | ChEMBL. | 7837229 |
IC50 (functional) | = 23.8 uM | Inhibitory activity against human platelet aggregation. | ChEMBL. | 7837229 |
logP (ADMET) | = 10.096 | Partition coefficient (logP) | ChEMBL. | 7837229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.