Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Arrow homolog | 0.0377 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0377 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0377 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0377 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0377 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0377 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0377 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0377 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0377 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.