Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | TYRA-2 protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.