Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.2575 | 0.651 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1282 | 0.2988 | 0.1506 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3857 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.2364 | 0.3041 |
Mycobacterium ulcerans | hydrolase | 0.1282 | 0.2988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1282 | 0.2988 | 0.4089 |
Onchocerca volvulus | 0.1451 | 0.3449 | 0.2945 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.2334 | 0.5854 | 0.9469 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1052 | 0.2364 | 0.3041 |
Loa Loa (eye worm) | hypothetical protein | 0.1124 | 0.2559 | 0.3369 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.2364 | 0.3041 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1124 | 0.2559 | 0.742 |
Brugia malayi | Hemopexin family protein | 0.1451 | 0.3449 | 0.2618 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1282 | 0.2988 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1282 | 0.2988 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.2334 | 0.5854 | 0.8898 |
Onchocerca volvulus | Matrilysin homolog | 0.2406 | 0.6049 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.2575 | 0.651 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1451 | 0.3449 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.