Detailed information for compound 845861

Basic information

Technical information
  • TDR Targets ID: 845861
  • Name: 2-(4-butyl-3,5-dimethylpyrazol-1-yl)-N-(4-chl orophenyl)-4-methyl-1,3-thiazole-5-carboxamid e
  • MW: 402.941 | Formula: C20H23ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 6.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1c(C)nn(c1C)c1nc(c(s1)C(=O)Nc1ccc(cc1)Cl)C
  • InChi: 1S/C20H23ClN4OS/c1-5-6-7-17-12(2)24-25(14(17)4)20-22-13(3)18(27-20)19(26)23-16-10-8-15(21)9-11-16/h8-11H,5-7H2,1-4H3,(H,23,26)
  • InChiKey: NVWRTLQEVYNFTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-butyl-3,5-dimethyl-pyrazol-1-yl)-N-(4-chlorophenyl)-4-methyl-thiazole-5-carboxamide
  • 2-(4-butyl-3,5-dimethyl-1-pyrazolyl)-N-(4-chlorophenyl)-4-methyl-5-thiazolecarboxamide
  • 2-(4-butyl-3,5-dimethyl-pyrazol-1-yl)-N-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Tachykinin-like peptides receptor 99D 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi GnHR receptor homolog 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi G protein-coupled receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0165 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0165 0 0.5
Brugia malayi Serotonin receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Schistosoma mansoni hypothetical protein 0.0175 0.2829 1
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi sulfakinin receptor protein 0.0165 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0165 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi Dopamine receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0165 0 0.5
Brugia malayi AKH receptor 0.0165 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Echinococcus multilocularis kinesin family 1 0.0201 1 1
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi Serotonin receptor 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi RE15519p 0.0165 0 0.5
Brugia malayi neuropeptide F receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0165 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0165 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0165 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi larval opioid receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0165 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi putative neuropeptide receptor 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Brugia malayi hypothetical protein 0.0165 0 0.5
Brugia malayi G-protein coupled receptor 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi G-protein coupled receptor 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0165 0 0.5
Onchocerca volvulus 0.0165 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0165 0 0.5
Brugia malayi neuropeptide F receptor 0.0165 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.