Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.033 | 0.2054 | 0.5445 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.1336 | 0.2833 |
Brugia malayi | hypothetical protein | 0.0501 | 0.3612 | 0.7431 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.2054 | 0.4362 |
Schistosoma mansoni | hypothetical protein | 0.0519 | 0.3772 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.2054 | 1 |
Schistosoma mansoni | jun-related protein | 0.0519 | 0.3772 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0638 | 0.4861 | 0.4861 |
Echinococcus granulosus | Ankyrin | 0.0105 | 0.0005 | 0.0005 |
Echinococcus granulosus | jun protein | 0.0638 | 0.4861 | 0.4861 |
Brugia malayi | bZIP transcription factor family protein | 0.0638 | 0.4861 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0638 | 0.4861 | 0.4861 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0105 | 0.0005 | 0.0013 |
Echinococcus multilocularis | Ankyrin | 0.0105 | 0.0005 | 0.0005 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.1202 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.2054 | 0.5 |
Onchocerca volvulus | 0.0501 | 0.3612 | 1 | |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.2054 | 0.4362 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.1336 | 0.2747 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.2054 | 0.4224 |
Echinococcus multilocularis | jun protein | 0.0638 | 0.4861 | 0.4861 |
Loa Loa (eye worm) | hypothetical protein | 0.0621 | 0.4702 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.