Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.155 | 0.1299 | 0.1562 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.3445 | 0.2951 | 0.3549 |
Schistosoma mansoni | hypothetical protein | 0.0895 | 0.0728 | 0.2468 |
Schistosoma mansoni | hypothetical protein | 0.0895 | 0.0728 | 0.2468 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.155 | 0.1299 | 0.1562 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1934 | 0.1634 | 0.1621 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0895 | 0.0728 | 0.0714 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0015 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0895 | 0.0728 | 0.0876 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.0018 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0895 | 0.0728 | 0.0714 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2829 | 0.2414 | 0.2403 |
Loa Loa (eye worm) | hypothetical protein | 0.155 | 0.1299 | 0.1286 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.3445 | 0.2951 | 0.3549 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1934 | 0.1634 | 0.5536 |
Schistosoma mansoni | hypothetical protein | 0.0895 | 0.0728 | 0.2468 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0895 | 0.0728 | 0.0876 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.1532 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0015 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0397 | 0.0294 | 0.0996 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0895 | 0.0728 | 0.2468 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.9598 | 0.8314 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0015 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0895 | 0.0728 | 0.0714 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0015 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0895 | 0.0728 | 0.0876 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0895 | 0.0728 | 0.0876 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0015 | 0.0051 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.9598 | 0.8314 | 1 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.3387 | 0.29 | 0.289 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.3445 | 0.2951 | 0.294 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.3445 | 0.2951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.155 | 0.1299 | 0.1286 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2829 | 0.2414 | 0.2403 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1934 | 0.1634 | 0.1621 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.155 | 0.1299 | 0.1286 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0015 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0895 | 0.0728 | 0.0714 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.