Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | kinesin, putative | 0.0053 | 0.0322 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0094 | 0.1463 | 0.8166 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0087 | 0.1268 | 0.1206 |
Brugia malayi | Kinesin motor domain containing protein | 0.0053 | 0.0322 | 0.0371 |
Plasmodium falciparum | kinesin-5 | 0.0053 | 0.0322 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0053 | 0.0322 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.239 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0118 | 0.2122 | 0.2237 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 0.8555 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0104 | 0.1731 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0053 | 0.0322 | 0.1349 |
Echinococcus multilocularis | kinesin family 1 | 0.0404 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0128 | 0.239 | 0.1285 |
Loa Loa (eye worm) | glutamate receptor | 0.0104 | 0.1731 | 0.7241 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0128 | 0.239 | 0.1285 |
Schistosoma mansoni | kinesin eg-5 | 0.0053 | 0.0322 | 0.0065 |
Plasmodium vivax | kinesin-5 | 0.0053 | 0.0322 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0053 | 0.0322 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.