Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0321 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0321 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0122 | 0.3401 | 0.3401 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3401 | 0.3401 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.0344 | 0.0344 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0321 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3401 | 0.3401 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0321 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0122 | 0.3401 | 0.3401 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0321 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0321 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0321 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0321 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.