Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.1252 | 0.0405 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0522 | 0.1765 | 0.1154 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.202 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0394 | 0.1065 | 0.0099 |
Brugia malayi | Matrixin family protein | 0.0428 | 0.1252 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1765 | 0.1242 |
Onchocerca volvulus | Matrilysin homolog | 0.1412 | 0.6661 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.095 | 0.412 | 0.5302 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0522 | 0.1765 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0394 | 0.1065 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0394 | 0.1065 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.1498 | 0.7132 | 1 |
Brugia malayi | Matrixin family protein | 0.1498 | 0.7132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.3793 | 0.4552 |
Brugia malayi | Matrixin family protein | 0.0428 | 0.1252 | 0.0308 |
Onchocerca volvulus | 0.0607 | 0.2236 | 0.1819 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0394 | 0.1065 | 0.0099 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0394 | 0.1065 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0522 | 0.1765 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0607 | 0.2236 | 0.193 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0394 | 0.1065 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0428 | 0.1252 | 0.0405 |
Mycobacterium tuberculosis | Possible exported protein | 0.1125 | 0.5083 | 1 |
Brugia malayi | Matrixin family protein | 0.0428 | 0.1252 | 0.0308 |
Brugia malayi | Matrixin family protein | 0.0428 | 0.1252 | 0.0308 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0394 | 0.1065 | 0.2057 |
Echinococcus granulosus | carbonic anhydrase II | 0.0394 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | matrixin family protein | 0.095 | 0.412 | 0.5085 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.1252 | 0.0405 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0891 | 0.3793 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0394 | 0.1065 | 0.2057 |
Schistosoma mansoni | hypothetical protein | 0.0607 | 0.2236 | 0.5466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.