Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0188 | 0.0093 |
Schistosoma mansoni | d-amino acid oxidase | 0.0351 | 1 | 1 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0029 | 0.0096 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0188 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0351 | 1 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0029 | 0.0096 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0029 | 0.0096 | 0.5 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0029 | 0.0096 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0345 | 0.9788 | 1 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0029 | 0.0096 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0029 | 0.0096 | 1 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0029 | 0.0096 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0029 | 0.0096 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0345 | 0.9788 | 0.9786 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.9788 | 0.9786 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0188 | 0.0095 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0188 | 0.0095 |
Echinococcus multilocularis | snurportin 1 | 0.0345 | 0.9788 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.2017 | 1 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0029 | 0.0096 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0029 | 0.0096 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0188 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0029 | 0.0096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0188 | 0.0093 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0029 | 0.0096 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0188 | 1 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0322 | 0.9099 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0351 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0096 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0096 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0029 | 0.0096 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0029 | 0.0096 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0188 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0188 | 0.0477 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0029 | 0.0096 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0188 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.