Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.3401 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0357 | 0.3401 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0357 | 0.3401 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0348 | 0.3297 | 0.9693 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0357 | 0.3401 | 1 |
Schistosoma mansoni | hypothetical protein | 0.044 | 0.4341 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0348 | 0.3297 | 0.9693 |
Mycobacterium ulcerans | hypothetical protein | 0.0183 | 0.1414 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0183 | 0.1414 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0348 | 0.3297 | 0.9525 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0348 | 0.3297 | 0.9525 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0165 | 0.1201 | 0.3531 |
Echinococcus granulosus | Desert hedgehog protein | 0.0604 | 0.6214 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1405 | 0.0967 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0357 | 0.3401 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.