Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0277 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0265 | 0.9238 | 0.1475 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0277 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.9106 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0851 | 0.0851 |
Trypanosoma cruzi | ion transport protein, putative | 0.0223 | 0.6565 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0263 | 0.9106 | 0.4744 |
Trypanosoma cruzi | ion transport protein, putative | 0.0223 | 0.6565 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.9106 | 0.9106 |
Leishmania major | ion transport protein-like protein | 0.0223 | 0.6565 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0277 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.