Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phospholipase D | 0.0971 | 0.8562 | 0.8562 |
Onchocerca volvulus | Putative phospholipase D | 0.0207 | 0 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.1099 | 1 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0383 | 0.1973 | 0.5 |
Echinococcus granulosus | phospholipase D1 | 0.1099 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0383 | 0.1973 | 0.1973 |
Entamoeba histolytica | phospholipase D, putative | 0.1099 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0971 | 0.8562 | 0.8562 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.5702 | 0.7103 |
Loa Loa (eye worm) | hypothetical protein | 0.0923 | 0.8027 | 1 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0923 | 0.8027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.5702 | 0.7103 |
Schistosoma mansoni | phospholipase D | 0.1099 | 1 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.0383 | 0.1973 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.1099 | 1 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0383 | 0.1973 | 0.5 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0383 | 0.1973 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0383 | 0.1973 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.