Detailed information for compound 865946

Basic information

Technical information
  • TDR Targets ID: 865946
  • Name: 3-(hydroxy-phenylamino)-1-(4-morpholin-4-ylph enyl)pyrrolidine-2,5-dione
  • MW: 367.398 | Formula: C20H21N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON(C1CC(=O)N(C1=O)c1ccc(cc1)N1CCOCC1)c1ccccc1
  • InChi: 1S/C20H21N3O4/c24-19-14-18(23(26)17-4-2-1-3-5-17)20(25)22(19)16-8-6-15(7-9-16)21-10-12-27-13-11-21/h1-9,18,26H,10-14H2
  • InChiKey: YAQYPGOJCGVCDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(hydroxy-phenyl-amino)-1-(4-morpholinophenyl)pyrrolidine-2,5-dione
  • 3-(hydroxy-phenylamino)-1-(4-morpholinophenyl)pyrrolidine-2,5-dione
  • 3-(hydroxy-phenyl-amino)-1-(4-morpholinophenyl)pyrrolidine-2,5-quinone
  • 3-(hydroxy-phenyl-amino)-1-(4-morpholin-4-ylphenyl)pyrrolidine-2,5-dione
  • Oprea1_581843
  • 3-(Hydroxy-phenyl-amino)-1-(4-morpholin-4-yl-phenyl)-pyrrolidine-2,5-dione
  • BAS 00786938
  • Oprea1_686074
  • ChemDiv3_003534
  • IDI1_021444

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0123 0.0786 0.0786
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0123 0.0786 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0232 0.0232
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0123 0.0786 0.5
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0123 0.0786 0.5
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0024 0.0304
Loa Loa (eye worm) hypothetical protein 0.0123 0.0786 0.0786
Leishmania major hypothetical protein, conserved 0.0123 0.0786 0.5
Brugia malayi cDNA sequence BC016226 0.0123 0.0786 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0024 0.0304
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0208 0.2651
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0123 0.0786 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0232 0.0232
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0123 0.0786 0.5
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0123 0.0786 0.5
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0123 0.0786 0.5
Schistosoma mansoni d-amino acid oxidase 0.1477 1 1
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0123 0.0786 0.0786
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0123 0.0786 0.5
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0123 0.0786 1
Leishmania major hypothetical protein, conserved 0.0123 0.0786 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0024 0.0024
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0024 0.0304
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0024 0.0024
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0123 0.0786 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0024
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0123 0.0786 0.5
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0123 0.0786 0.0786
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0191 1
Onchocerca volvulus Putative fad oxidoreductase 0.0123 0.0786 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0174 0.0174
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0123 0.0786 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0191 1
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0123 0.0786 0.5
Schistosoma mansoni NAD dehydrogenase 0.0123 0.0786 0.0786
Mycobacterium ulcerans D-amino acid oxidase Aao 0.1477 1 1
Schistosoma mansoni fad oxidoreductase 0.0123 0.0786 0.0786
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0123 0.0786 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0123 0.0786 0.5
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0123 0.0786 1
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0123 0.0786 1
Chlamydia trachomatis D-amino acid dehydrogenase 0.0123 0.0786 0.5
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0123 0.0786 0.5
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0123 0.0786 0.5
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0123 0.0786 0.5
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.1477 1 1
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0123 0.0786 0.5
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0123 0.0786 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0024 0.0304
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0123 0.0786 0.5
Loa Loa (eye worm) hypothetical protein 0.0123 0.0786 0.0786
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.1353 0.9162 1
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0123 0.0786 0.0786
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0024 0.0304
Toxoplasma gondii hypothetical protein 0.0123 0.0786 0.5
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0123 0.0786 0.5
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0123 0.0786 1
Brugia malayi RE18450p 0.0123 0.0786 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0208 0.0208
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0123 0.0786 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0208 0.2651
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0208 0.2651
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0123 0.0786 1
Schistosoma mansoni fad oxidoreductase 0.0123 0.0786 0.0786

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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