Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0271 | 0.1308 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0504 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0504 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0271 | 0.1308 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0271 | 0.1308 | 0.1308 |
Chlamydia trachomatis | peptide deformylase | 0.0271 | 0.1308 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0271 | 0.1308 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0504 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0504 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0271 | 0.1308 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0504 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0271 | 0.1308 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.