Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0259 | 0.309 | 0.309 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0679 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0232 | 0.2644 | 0.2234 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0131 | 0.0986 | 0.0986 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0679 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0103 | 0.0528 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0259 | 0.309 | 0.2705 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0679 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0259 | 0.309 | 0.309 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0259 | 0.309 | 0.309 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0679 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0103 | 0.0528 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0131 | 0.0986 | 0.0986 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0259 | 0.309 | 0.2705 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0679 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0679 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0679 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0131 | 0.0986 | 0.0986 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0259 | 0.309 | 0.309 |
Echinococcus granulosus | carbonic anhydrase II | 0.0131 | 0.0986 | 0.0986 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0679 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.1543 | 0.1543 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0259 | 0.309 | 0.2705 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.309 | 0.309 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1543 | 0.1543 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0679 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0131 | 0.0986 | 0.0986 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0259 | 0.309 | 0.309 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0131 | 0.0986 | 0.0483 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0679 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0679 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0131 | 0.0986 | 0.0986 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1543 | 0.1543 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0679 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0131 | 0.0986 | 0.0483 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0679 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0131 | 0.0986 | 0.0986 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0679 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0679 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1543 | 0.1543 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0131 | 0.0986 | 0.0483 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0679 | 1 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0679 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0131 | 0.0986 | 0.0483 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0679 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0131 | 0.0986 | 0.0986 |
Toxoplasma gondii | prolyl endopeptidase | 0.0259 | 0.309 | 0.309 |
Plasmodium vivax | RNA helicase-1, putative | 0.0679 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0679 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0679 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0679 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.