Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | CREB binding protein | 0.0037 | 0.0085 | 0.0103 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0157 | 0.5262 | 0.3167 |
Echinococcus multilocularis | CREB binding protein | 0.0037 | 0.0085 | 0.0163 |
Brugia malayi | TAZ zinc finger family protein | 0.0226 | 0.8244 | 0.8244 |
Echinococcus multilocularis | CREB binding protein | 0.0037 | 0.0085 | 0.0163 |
Echinococcus granulosus | CREB binding protein | 0.0226 | 0.8244 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 1 | 1 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0226 | 0.8244 | 0.8244 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0266 | 1 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0139 | 0.4504 | 0.5463 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | CREB binding protein | 0.0037 | 0.0085 | 0.0163 |
Echinococcus multilocularis | CREB binding protein | 0.0155 | 0.5177 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0226 | 0.8244 | 0.8244 |
Echinococcus granulosus | CREB binding protein | 0.0037 | 0.0085 | 0.0103 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.