Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0685 | 0.9902 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0685 | 0.9902 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0676 | 0.9495 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0687 | 1 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0676 | 0.9495 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0676 | 0.9495 | 1 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0685 | 0.9902 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.