Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | calcium-activated potassium channel | 0.005 | 1 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0036 | 0.2437 | 0.5 |
Brugia malayi | Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog | 0.0033 | 0.1292 | 0.5303 |
Echinococcus multilocularis | calcium activated potassium channel | 0.005 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0036 | 0.2437 | 0.2978 |
Brugia malayi | Bm-MIF-1, identical | 0.0036 | 0.2437 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0036 | 0.2437 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0036 | 0.2437 | 0.2978 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0036 | 0.2437 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0036 | 0.2437 | 0.2978 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0036 | 0.2437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1292 | 0.1579 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0036 | 0.2437 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0036 | 0.2437 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.2437 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0047 | 0.8185 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0036 | 0.2437 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Loa Loa (eye worm) | MaxiK calcium-activated potassium channel | 0.0033 | 0.1292 | 0.1579 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | potassium large conductance calcium activated | 0.005 | 1 | 1 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.005 | 1 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0036 | 0.2437 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.