Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.022 | 0.6509 | 0.6893 |
Loa Loa (eye worm) | matrixin family protein | 0.022 | 0.6509 | 0.6826 |
Brugia malayi | ADAMTS-like protease | 0.0086 | 0.0079 | 0.0083 |
Onchocerca volvulus | Matrilysin homolog | 0.0208 | 0.5936 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0117 | 0.1578 | 0.6453 |
Onchocerca volvulus | Papilin homolog | 0.0089 | 0.02 | 0.0337 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0135 | 0.2445 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0132 | 0.2293 | 0.2265 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.2445 | 0.2429 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0292 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0132 | 0.2293 | 0.3863 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0281 | 0.9443 | 1 |
Brugia malayi | angiogenesis inhibito | 0.0086 | 0.0079 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.9443 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.