Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.787 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.3502 | 0.445 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.9688 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3502 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3502 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3502 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0092 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0092 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0075 | 0.787 | 1 |
Echinococcus multilocularis | jun protein | 0.0092 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0.7559 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0092 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.3502 | 0.3502 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3502 | 0.5 |
Brugia malayi | hypothetical protein | 0.0072 | 0.7559 | 0.7559 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.3502 | 0.3502 |
Brugia malayi | hypothetical protein | 0.0039 | 0.3502 | 0.3502 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.3502 | 0.445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.