Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.0551 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1453 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1453 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.3164 | 0.3164 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.046 | 0.8342 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0937 | 0.6325 | 0.6012 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.046 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.0551 | 1 |
Leishmania major | trypanothione reductase | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.046 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.0551 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.0551 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.046 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.046 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.046 | 0.8342 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0863 | 0.5794 | 0.5794 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1453 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.2973 | 0.2973 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1453 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.