Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | prolyl endopeptidase | 0.0152 | 0.2524 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0152 | 0.2524 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0152 | 0.2524 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0152 | 0.2524 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0152 | 0.2524 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0152 | 0.2524 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.006 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0152 | 0.2524 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.006 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0152 | 0.2524 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0136 | 0.2084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.2524 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.