Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0015 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0029 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0029 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0029 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0029 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0029 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0015 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0029 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0029 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0029 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0029 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0029 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0029 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0029 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0029 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0015 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0029 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0029 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0029 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0029 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0029 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0029 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0015 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0029 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0029 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0029 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0029 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0029 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0029 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0029 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0029 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0015 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0029 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0029 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0029 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0029 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0029 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0015 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.