Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0998 | 0.8818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.077 | 0.077 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0805 | 0.6773 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0873 | 0.7492 | 0.8496 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0202 | 0.0403 | 0.0403 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0873 | 0.7492 | 0.8496 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0365 | 0.2124 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.111 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 0.6138 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.111 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0998 | 0.8818 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0365 | 0.2124 | 0.2124 |
Brugia malayi | Probable DNA topoisomerase II | 0.111 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0805 | 0.6773 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0602 | 0.4632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 0.6138 | 0.6138 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0873 | 0.7492 | 0.8496 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.111 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.111 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.1061 | 0.9481 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.111 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0365 | 0.2124 | 0.2124 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0365 | 0.2124 | 0.2124 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0202 | 0.0403 | 0.0403 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0998 | 0.8818 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.111 | 1 | 0.5 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0238 | 0.0776 | 0.0191 |
Toxoplasma gondii | MAPEG family protein | 0.0221 | 0.0597 | 0.0597 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0202 | 0.0403 | 0.0403 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0365 | 0.2124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.3695 | 0.3695 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0998 | 0.8818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.077 | 0.077 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0652 | 0.5157 | 0.5157 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.077 | 0.077 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0365 | 0.2124 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0365 | 0.2124 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.111 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.3451 | 0.3451 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0365 | 0.2124 | 0.407 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0805 | 0.6773 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0963 | 0.845 | 0.8351 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0998 | 0.8818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.3451 | 0.3451 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.111 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.