Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.6208 | 0.3458 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.8166 | 0.4656 | 0.4275 |
Trypanosoma cruzi | metacaspase 5, putative | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 1.6901 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1644 | 0.0666 | 0.1431 |
Echinococcus multilocularis | caspase 3 | 1.0694 | 0.6203 | 0.5931 |
Leishmania major | metacaspase, putative | 0.6208 | 0.3458 | 0.5 |
Trypanosoma brucei | metacaspase MCA2 | 0.6208 | 0.3458 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Echinococcus granulosus | caspase 3 | 1.0694 | 0.6203 | 0.5931 |
Trypanosoma cruzi | metacaspase, putative | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.8166 | 0.4656 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.6208 | 0.3458 | 0.5 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.6208 | 0.3458 | 0.2991 |
Plasmodium vivax | metacaspase 1, putative | 0.6208 | 0.3458 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.6208 | 0.3458 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.6208 | 0.3458 | 0.7376 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.8166 | 0.4656 | 0.4275 |
Plasmodium falciparum | metacaspase 1 | 0.6208 | 0.3458 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 1.6901 | 1 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.6208 | 0.3458 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.6208 | 0.3458 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Echinococcus granulosus | caspase | 1.6901 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.8166 | 0.4656 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Echinococcus multilocularis | caspase | 1.6901 | 1 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.8166 | 0.4656 | 1 |
Echinococcus multilocularis | caspase 8 | 0.6208 | 0.3458 | 0.2991 |
Trypanosoma brucei | metacaspase | 0.6208 | 0.3458 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 1.6901 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.8166 | 0.4656 | 0.4275 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Plasmodium falciparum | metacaspase-like protein | 0.6208 | 0.3458 | 0.5 |
Brugia malayi | hypothetical protein | 0.1644 | 0.0666 | 0.126 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.6208 | 0.3458 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.6208 | 0.3458 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.6208 | 0.3458 | 0.2991 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6208 | 0.3458 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6208 | 0.3458 | 0.7427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.