Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0714 | 0.4549 | 0.4549 |
Echinococcus multilocularis | Ankyrin | 0.0129 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.058 | 0.351 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.1417 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0561 | 0.3358 | 0.7383 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0129 | 0.0005 | 0.0014 |
Echinococcus granulosus | Ankyrin | 0.0129 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0561 | 0.3358 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0714 | 0.4549 | 0.4549 |
Echinococcus multilocularis | jun protein | 0.0714 | 0.4549 | 0.4549 |
Schistosoma mansoni | jun-related protein | 0.058 | 0.351 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0714 | 0.4549 | 1 |
Echinococcus granulosus | jun protein | 0.0714 | 0.4549 | 0.4549 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 0.4397 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.