Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0172 | 0.0916 | 0.0349 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.1336 | 1 | 1 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.1336 | 1 | 1 |
Brugia malayi | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 0.013 | 0.0588 | 0.0588 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.1336 | 1 | 0.5 |
Leishmania major | S-adenosylmethionine decarboxylase | 0.1336 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0916 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0651 | 0.4651 | 0.5 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0651 | 0.4651 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0916 | 1 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.1336 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0172 | 0.0916 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0588 | 0.0588 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.1336 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.1336 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.1336 | 1 | 0.5 |
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.1336 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.