Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.076 | 0.0688 |
Echinococcus granulosus | histone deacetylase 6 | 0.1653 | 0.6481 | 0.6481 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.095 | 0.272 | 0.272 |
Leishmania major | histone deacetylase, putative | 0.2311 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.2311 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0455 | 0.0077 | 0.0077 |
Trypanosoma brucei | histone deacetylase 2 | 0.095 | 0.272 | 0.2664 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1653 | 0.6481 | 0.6481 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0455 | 0.0077 | 0.0077 |
Plasmodium falciparum | histone deacetylase 1 | 0.2311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1063 | 0.0994 |
Leishmania major | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Echinococcus multilocularis | serotonin receptor | 0.0583 | 0.076 | 0.076 |
Echinococcus granulosus | histone deacetylase 7 | 0.1589 | 0.614 | 0.614 |
Schistosoma mansoni | histone deacetylase hda2 | 0.095 | 0.272 | 0.272 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.1589 | 0.614 | 0.611 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.095 | 0.272 | 0.2664 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.2311 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2311 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.1589 | 0.614 | 0.611 |
Echinococcus multilocularis | histone deacetylase 3 | 0.2311 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Echinococcus granulosus | histone deacetylase 6 | 0.1589 | 0.614 | 0.614 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2311 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.2311 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0583 | 0.076 | 0.076 |
Echinococcus granulosus | histone deacetylase | 0.1589 | 0.614 | 0.614 |
Echinococcus granulosus | histone deacetylase 8 | 0.095 | 0.272 | 0.272 |
Echinococcus multilocularis | histone deacetylase 7 | 0.1589 | 0.614 | 0.614 |
Echinococcus granulosus | histone deacetylase 3 | 0.2311 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0455 | 0.0077 | 0.0077 |
Trypanosoma cruzi | histone deacetylase, putative | 0.095 | 0.272 | 0.2664 |
Echinococcus multilocularis | histone deacetylase 1 | 0.2311 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1589 | 0.614 | 0.614 |
Brugia malayi | Histone deacetylase family protein | 0.1589 | 0.614 | 0.611 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.095 | 0.272 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.095 | 0.272 | 0.2664 |
Echinococcus granulosus | histone deacetylase 1 | 0.2311 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.2311 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1589 | 0.614 | 0.614 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2311 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1589 | 0.614 | 0.614 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0455 | 0.0077 | 0.0077 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1653 | 0.6481 | 0.6481 |
Trypanosoma brucei | histone deacetylase 3 | 0.1589 | 0.614 | 0.611 |
Echinococcus granulosus | hypothetical protein | 0.0765 | 0.1735 | 0.1735 |
Plasmodium vivax | histone deacetylase, putative | 0.1589 | 0.614 | 0.4698 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0703 | 0.1404 | 0.1337 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.1589 | 0.614 | 0.4698 |
Echinococcus multilocularis | serotonin receptor | 0.0583 | 0.076 | 0.076 |
Plasmodium vivax | histone deacetylase 1, putative | 0.2311 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0583 | 0.076 | 0.0688 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Echinococcus multilocularis | histone deacetylase | 0.1589 | 0.614 | 0.614 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1589 | 0.614 | 0.611 |
Loa Loa (eye worm) | hypothetical protein | 0.095 | 0.272 | 0.2664 |
Brugia malayi | Histone deacetylase 1 | 0.2311 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.1589 | 0.614 | 0.4698 |
Brugia malayi | histone deacetylase 11 | 0.095 | 0.272 | 0.2664 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.1589 | 0.614 | 0.611 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0583 | 0.076 | 0.076 |
Leishmania major | histone deacetylase, putative | 0.2311 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1589 | 0.614 | 0.614 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2311 | 1 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.2311 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 8 | 0.095 | 0.272 | 0.272 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2311 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.1589 | 0.614 | 0.614 |
Schistosoma mansoni | histone deacetylase | 0.2311 | 1 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0714 | 0.1461 | 0.1461 |
Loa Loa (eye worm) | hypothetical protein | 0.2311 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.2311 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.1589 | 0.614 | 0.611 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.2311 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.2311 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.