Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.011 | 0.2125 | 0.2125 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2125 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2125 | 0.5 |
Brugia malayi | hypothetical protein | 0.011 | 0.2125 | 0.2125 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Loa Loa (eye worm) | aminopeptidase N | 0.011 | 0.2125 | 0.2403 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2125 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0159 | 0.3581 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2125 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.011 | 0.2125 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Onchocerca volvulus | 0.011 | 0.2125 | 0.2125 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Entamoeba histolytica | aminopeptidase, putative | 0.011 | 0.2125 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.6715 | 0.7592 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.8845 | 1 |
Onchocerca volvulus | 0.0375 | 1 | 1 | |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0159 | 0.3581 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.011 | 0.2125 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.011 | 0.2125 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.011 | 0.2125 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.011 | 0.2125 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2125 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0375 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0072 | 0.097 | 0.097 |
Echinococcus granulosus | aminopeptidase N | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.097 | 0.1097 |
Brugia malayi | Peptidase family M1 containing protein | 0.011 | 0.2125 | 0.2125 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2125 | 0.2125 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0072 | 0.097 | 0.4565 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2125 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.011 | 0.2125 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.097 | 0.1097 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0303 | 0.787 | 0.8898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.