Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0976 | 0.3837 | 0.3555 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0976 | 0.3837 | 0.3555 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1944 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1944 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0774 | 0.2552 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0774 | 0.2552 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0774 | 0.2552 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1944 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0976 | 0.3837 | 0.3573 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0774 | 0.2552 | 0.2552 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1944 | 1 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0774 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0972 | 0.381 | 0.381 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1944 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0774 | 0.2552 | 0.2211 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0774 | 0.2552 | 0.2211 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0378 | 0.0027 | 0.0027 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0774 | 0.2552 | 0.2211 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0774 | 0.2552 | 0.5 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0972 | 0.381 | 0.381 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0976 | 0.3837 | 0.3555 |
Brugia malayi | Protein kinase domain containing protein | 0.0378 | 0.0027 | 0.0027 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0774 | 0.2552 | 0.2211 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0774 | 0.2552 | 0.2211 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0774 | 0.2552 | 0.2211 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0378 | 0.0027 | 0.0027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.