Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | peptide deformylase | 0.045 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0172 | 0.3368 | 0.5 |
Toxoplasma gondii | PLU-1 family protein | 0.0046 | 0.037 | 0.0291 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0083 | 0.1248 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.045 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.045 | 1 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0129 | 0.2343 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.045 | 1 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0105 | 0.1773 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.3368 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0172 | 0.3368 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.3368 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0172 | 0.3368 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.3368 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.3368 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0129 | 0.2343 | 0.5 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0105 | 0.1773 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.045 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.045 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.045 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.045 | 1 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0083 | 0.1248 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.