TDR Targets

Basic information

Technical information

TDR Targets ID: 884883
Name: 3-(2-bromophenyl)-1-[2,2-di(phenyl)ethyl]urea
MW: 395.292 | Formula: C21H19BrN2O
H donors: 2 H acceptors: 1 LogP: 5.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1Br)NCC(c1ccccc1)c1ccccc1
InChi: 1S/C21H19BrN2O/c22-19-13-7-8-14-20(19)24-21(25)23-15-18(16-9-3-1-4-10-16)17-11-5-2-6-12-17/h1-14,18H,15H2,(H2,23,24,25)
InChiKey: IUXRJRZYMTVPMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_708856

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Schistosoma mansoni	tyrosine kinase	0.0024	0.0676	0.069
Schistosoma mansoni	tyrosine kinase	0.0082	0.4432	0.4527
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0334	0.0317
Onchocerca volvulus	Protein cycle homolog	0.0019	0.0351	0.3942
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0147	0.8694	0.8692
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0085	0.4678	0.477
Schistosoma mansoni	adapter molecule crk	0.002	0.0429	0.0438
Loa Loa (eye worm)	hypothetical protein	0.002	0.0429	0.0413
Schistosoma mansoni	tyrosine kinase	0.0156	0.9323	0.9524
Brugia malayi	hypothetical protein	0.0019	0.0334	0.0317
Schistosoma mansoni	growth factor receptor-bound protein	0.002	0.0429	0.0438
Echinococcus multilocularis	activin receptor type	0.0078	0.4183	0.4263
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Echinococcus multilocularis	NCK adaptor protein	0.002	0.0429	0.0422
Schistosoma mansoni	tyrosine kinase	0.0082	0.4432	0.4527
Schistosoma mansoni	tyrosine kinase	0.0052	0.2492	0.2546
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0024	0.0676	0.0674
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0024	0.0676	0.0674
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0019	0.0334	0.0317
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0024	0.0676	0.0674
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0027	0.0883	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0146	0.8658	0.8656
Echinococcus multilocularis	epidermal growth factor receptor	0.0156	0.9323	0.9523
Brugia malayi	SRC-1	0.0024	0.0676	0.066
Schistosoma mansoni	protein kinase	0.0123	0.7146	0.7299
Echinococcus granulosus	aryl hydrocarbon receptor	0.0027	0.0883	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0334	0.0317
Loa Loa (eye worm)	TK/INSR protein kinase	0.0052	0.2492	0.248
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0167	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0024	0.0676	0.0674
Schistosoma mansoni	tyrosine kinase	0.0024	0.0676	0.069
Echinococcus multilocularis	protein kinase	0.0123	0.7146	0.7295
Echinococcus granulosus	protein kinase	0.0123	0.7146	0.7295
Schistosoma mansoni	tyrosine kinase	0.0085	0.4678	0.4779
Echinococcus granulosus	insulin receptor	0.0052	0.2492	0.2533
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0052	0.2492	0.2533
Brugia malayi	Variant SH3 domain containing protein	0.002	0.0429	0.0413
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0024	0.0676	0.0674
Echinococcus granulosus	c src tyrosine kinase	0.0024	0.0676	0.0674
Echinococcus multilocularis	growth factor receptor bound protein 2	0.002	0.0429	0.0422
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0161	0.9605	0.9811
Schistosoma mansoni	tyrosine kinase	0.0151	0.8946	0.9138
Loa Loa (eye worm)	SRC-1	0.0024	0.0676	0.066
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0024	0.0676	0.0674
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0052	0.2492	0.2533
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0019	0.0351	0.0359
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0024	0.0676	0.0674
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Echinococcus granulosus	epidermal growth factor receptor	0.0085	0.4678	0.477
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0334	0.0317
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0161	0.9605	0.9811
Brugia malayi	protein C17H12.11	0.0146	0.8658	0.8656
Brugia malayi	hypothetical protein	0.0027	0.0866	0.085
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0019	0.0351	0.0335
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0025	0.0712	0.0711
Echinococcus granulosus	NCK adaptor protein	0.002	0.0429	0.0422
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0014	0.0017	0.5
Echinococcus granulosus	activin receptor type	0.0078	0.4183	0.4263
Brugia malayi	Variant SH3 domain containing protein	0.002	0.0429	0.0413
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Echinococcus multilocularis	c src tyrosine kinase	0.0024	0.0676	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0866	0.085
Schistosoma mansoni	tyrosine kinase	0.0052	0.2492	0.2546
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0024	0.0676	0.0674
Echinococcus granulosus	growth factor receptor bound protein 2	0.002	0.0429	0.0422
Schistosoma mansoni	protein kinase	0.0123	0.7146	0.7299
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0676	0.0674
Onchocerca volvulus		0.0027	0.0866	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0156	0.9323	0.9322
Echinococcus multilocularis	epidermal growth factor receptor	0.0085	0.4678	0.477
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.002	0.0429	0.0413
Brugia malayi	Sex muscle abnormal protein 5	0.002	0.0429	0.0413
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0019	0.0351	0.0335
Brugia malayi	hypothetical protein	0.0146	0.8658	0.8656
Schistosoma mansoni	nck2/grb4	0.002	0.0429	0.0438
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0074	0.3936	0.401
Echinococcus granulosus	TGF-beta receptor type-1	0.0163	0.979	1
Echinococcus multilocularis		0.0047	0.2202	0.2236
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.002	0.0429	0.0413
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0019	0.0351	0.0335
Echinococcus multilocularis	insulin receptor	0.0052	0.2492	0.2533
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0024	0.0676	0.0674
Schistosoma mansoni	tyrosine kinase	0.0082	0.4432	0.4527
Schistosoma mansoni	growth factor receptor-bound protein	0.002	0.0429	0.0438
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0024	0.0676	0.0674
Schistosoma mansoni	tyrosine kinase	0.0024	0.0676	0.069
Brugia malayi	Protein kinase domain containing protein	0.0052	0.2492	0.248
Schistosoma mansoni	tyrosine kinase	0.0024	0.0676	0.069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0334	0.0317
Echinococcus granulosus	TGF beta receptor type 1	0.0163	0.979	1
Brugia malayi	activin receptor:ISOTYPE=IIA.	0.012	0.6935	0.693
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.002	0.0429	0.0438
Schistosoma mansoni	protein kinase	0.0077	0.4146	0.4236
Schistosoma mansoni	protein kinase	0.0163	0.979	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0024	0.0676	0.0674
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0156	0.9323	0.9322
Brugia malayi	Tyrosine-protein kinase abl-1	0.0024	0.0676	0.066
Echinococcus multilocularis	TGF beta receptor type 1	0.0163	0.979	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0676	0.069
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0027	0.0883	0.0868
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0147	0.8694	0.8692
Echinococcus granulosus	epidermal growth factor receptor	0.0156	0.9323	0.9523
Brugia malayi	hypothetical protein	0.0019	0.0351	0.0335
Schistosoma mansoni	tyrosine kinase	0.0085	0.4678	0.4779
Brugia malayi	Protein kinase domain containing protein	0.0147	0.8694	0.8692
Schistosoma mansoni	tyrosine kinase	0.0014	0.0017	0.0017

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 884883