Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Onchocerca volvulus | 0.0026 | 0.0866 | 1 | |
Schistosoma mansoni | protein kinase | 0.0118 | 0.7146 | 0.7299 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.002 | 0.0429 | 0.0422 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0023 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.005 | 0.2492 | 0.2546 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.002 | 0.0429 | 0.0413 |
Brugia malayi | hypothetical protein | 0.014 | 0.8658 | 0.8656 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0018 | 0.0351 | 0.0335 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.002 | 0.0429 | 0.0413 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0082 | 0.4678 | 0.477 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.015 | 0.9323 | 0.9322 |
Echinococcus granulosus | NCK adaptor protein | 0.002 | 0.0429 | 0.0422 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0024 | 0.0712 | 0.0711 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0018 | 0.0351 | 0.0335 |
Brugia malayi | protein C17H12.11 | 0.014 | 0.8658 | 0.8656 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0866 | 0.085 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0154 | 0.9605 | 0.9811 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0317 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0082 | 0.4678 | 0.477 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0866 | 0.085 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0023 | 0.0676 | 0.0674 |
Brugia malayi | Variant SH3 domain containing protein | 0.002 | 0.0429 | 0.0413 |
Schistosoma mansoni | protein kinase | 0.0074 | 0.4146 | 0.4236 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0014 | 0.0017 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0023 | 0.0676 | 0.069 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0157 | 0.979 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.015 | 0.9323 | 0.9322 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0023 | 0.0676 | 0.066 |
Schistosoma mansoni | protein kinase | 0.0157 | 0.979 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0023 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0017 | 0.0017 |
Brugia malayi | Protein kinase domain containing protein | 0.0141 | 0.8694 | 0.8692 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.4678 | 0.4779 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0141 | 0.8694 | 0.8692 |
Echinococcus granulosus | epidermal growth factor receptor | 0.015 | 0.9323 | 0.9523 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0351 | 0.0335 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0026 | 0.0883 | 0.0868 |
Echinococcus multilocularis | insulin receptor | 0.005 | 0.2492 | 0.2533 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0023 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0018 | 0.0351 | 0.0335 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0071 | 0.3936 | 0.401 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0157 | 0.979 | 1 |
Echinococcus multilocularis | 0.0045 | 0.2202 | 0.2236 | |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.002 | 0.0429 | 0.0413 |
Schistosoma mansoni | nck2/grb4 | 0.002 | 0.0429 | 0.0438 |
Echinococcus multilocularis | activin receptor type | 0.0074 | 0.4183 | 0.4263 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.002 | 0.0429 | 0.0438 |
Brugia malayi | activin receptor:ISOTYPE=IIA. | 0.0115 | 0.6935 | 0.693 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0157 | 0.979 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0317 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.2492 | 0.248 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0676 | 0.069 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0676 | 0.069 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0023 | 0.0676 | 0.0674 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.002 | 0.0429 | 0.0438 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.4432 | 0.4527 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.4432 | 0.4527 |
Echinococcus multilocularis | NCK adaptor protein | 0.002 | 0.0429 | 0.0422 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0018 | 0.0334 | 0.0317 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0023 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0023 | 0.0676 | 0.0674 |
Schistosoma mansoni | tyrosine kinase | 0.005 | 0.2492 | 0.2546 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0082 | 0.4678 | 0.477 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0141 | 0.8694 | 0.8692 |
Onchocerca volvulus | Protein cycle homolog | 0.0018 | 0.0351 | 0.3942 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0317 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0676 | 0.069 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.4432 | 0.4527 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Echinococcus granulosus | activin receptor type | 0.0074 | 0.4183 | 0.4263 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.002 | 0.0429 | 0.0438 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0334 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0429 | 0.0413 |
Schistosoma mansoni | tyrosine kinase | 0.015 | 0.9323 | 0.9524 |
Schistosoma mansoni | adapter molecule crk | 0.002 | 0.0429 | 0.0438 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0154 | 0.9605 | 0.9811 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.002 | 0.0429 | 0.0422 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0023 | 0.0676 | 0.0674 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0023 | 0.0676 | 0.0674 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.005 | 0.2492 | 0.2533 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0018 | 0.0351 | 0.0359 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0023 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | SRC-1 | 0.0023 | 0.0676 | 0.066 |
Schistosoma mansoni | tyrosine kinase | 0.0144 | 0.8946 | 0.9138 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0317 |
Schistosoma mansoni | protein kinase | 0.0118 | 0.7146 | 0.7299 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.015 | 0.9323 | 0.9523 |
Brugia malayi | SRC-1 | 0.0023 | 0.0676 | 0.066 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0026 | 0.0883 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.8658 | 0.8656 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0026 | 0.0883 | 0.0887 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0023 | 0.0676 | 0.0674 |
Echinococcus granulosus | c src tyrosine kinase | 0.0023 | 0.0676 | 0.0674 |
Brugia malayi | Variant SH3 domain containing protein | 0.002 | 0.0429 | 0.0413 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0023 | 0.0676 | 0.0674 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.005 | 0.2492 | 0.2533 |
Echinococcus granulosus | insulin receptor | 0.005 | 0.2492 | 0.2533 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0676 | 0.069 |
Echinococcus multilocularis | protein kinase | 0.0118 | 0.7146 | 0.7295 |
Echinococcus granulosus | protein kinase | 0.0118 | 0.7146 | 0.7295 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.4678 | 0.4779 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0023 | 0.0676 | 0.0674 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.005 | 0.2492 | 0.248 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.016 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.